GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7577851 | 1 | rs6749509 | chr2:69739714 | AAK1 | chr2:69685127-69870977:- | -0.24 | -5.13 | 4.28E-7 | Parkinson's disease (age of onset) |
| THCA | cis | rs7577851 | 1 | rs6749509 | chr2:69739714 | NFU1 | chr2:69623255-69664753:- | -0.17 | -3.78 | 0.000176 | Parkinson's disease (age of onset) |
| THCA | cis | rs4665809 | 1 | rs6749855 | chr2:26255263 | GPR113 | chr2:26531041-26569685:- | -0.44 | -6.75 | 4.38E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs12780845 | 1 | rs67505314 | chr10:17240134 | TRDMT1 | chr10:17184983-17243681:- | -0.42 | -9.92 | 3.31E-21 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs67505314 | chr10:17240134 | VIM | chr10:17270258-17279592:+ | -0.19 | -3.52 | 0.000467 | Homocysteine levels |
| THCA | cis | rs9308731 | 1 | rs6750599 | chr2:111893869 | BCL2L11 | chr2:111878491-111926022:+ | 0.14 | 3.58 | 0.000376 | Chronic lymphocytic leukemia |
| THCA | cis | rs4665809 | 1 | rs6750681 | chr2:26329677 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.71 | 5.42E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs2241437 | 1 | rs6750765 | chr2:86300308 | LOC90784 | chr2:86247339-86250991:- | -0.38 | -3.99 | 7.7E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs2241437 | 1 | rs6750765 | chr2:86300308 | POLR1A | chr2:86253453-86333278:- | -0.26 | -3.64 | 0.000298 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs6547741 | 1 | rs6750943 | chr2:27777904 | FNDC4 | chr2:27714751-27718126:- | -0.15 | -3.64 | 0.000304 | Oral cavity cancer |
| THCA | cis | rs6748734 | 1 | rs6751693 | chr2:241837332 | C2orf54 | chr2:241825466-241835573:- | 0.29 | 6.16 | 1.56E-9 | Urinary metabolites |
| THCA | cis | rs7116495 | 1 | rs675185 | chr11:71775572 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs3771570 | 1 | rs6752050 | chr2:242228780 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.24 | 2.71E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs6752050 | chr2:242228780 | SEPT2 | chr2:242254723-242293439:+ | -0.28 | -4.23 | 2.84E-5 | Prostate cancer |
| THCA | cis | rs3820928 | 1 | rs6752707 | chr2:227766822 | COL4A4 | chr2:227867435-228029275:- | 0.15 | 3.8 | 0.000166 | Pulmonary function |